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. 1998 Jan 2;279(5347):95-8.
doi: 10.1126/science.279.5347.95.

Discrete start sites for DNA synthesis in the yeast ARS1 origin

A K Bielinsky  1 , S A Gerbi
Affiliations

Discrete start sites for DNA synthesis in the yeast ARS1 origin

A K Bielinsky et al. Science. .

Abstract

Sites of DNA synthesis initiation have been detected at the nucleotide level in a yeast origin of bidirectional replication with the use of replication initiation point mapping. The ARS1 origin of Saccharomyces cerevisiae showed a transition from discontinuous to continuous DNA synthesis in an 18-base pair region (nucleotides 828 to 845) from within element B1 toward B2, adjacent to the binding site for the origin recognition complex, the putative initiator protein.

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