doi: 10.1006/cyto.1997.0304.
Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes
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- PMID: 9417812
- DOI: 10.1006/cyto.1997.0304
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Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes
Cytokine.
1997 Dec.
Abstract
Dihomogammalinolenic acid is derived from gammalinolenic acid, administration of which suppresses joint inflammation. It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide. Effects of eicosapentaenoic acid (EPA) on IL-1beta production are minimal, and palmitic acid (PA) does not influence IL-1beta production.
Copyright 1997 Academic Press Limited.
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