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. 1997 Dec;9(12):1008-12.
doi: 10.1006/cyto.1997.0304.

Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes

D Rothman  1 , H Allen, L Herzog, A Pilapil, C M Seiler, R B Zurier
Affiliations

Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes

D Rothman et al. Cytokine. 1997 Dec.

Abstract

Dihomogammalinolenic acid is derived from gammalinolenic acid, administration of which suppresses joint inflammation. It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide. Effects of eicosapentaenoic acid (EPA) on IL-1beta production are minimal, and palmitic acid (PA) does not influence IL-1beta production.

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