Review
doi: 10.1006/excr.1997.3776.
The retinoblastoma protein pathway in cell cycle control and cancer
Affiliations
- PMID: 9417859
- DOI: 10.1006/excr.1997.3776
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Review
The retinoblastoma protein pathway in cell cycle control and cancer
Exp Cell Res.
.
Abstract
Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.
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