Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Nov 25;237(1):1-6.
doi: 10.1006/excr.1997.3776.

The retinoblastoma protein pathway in cell cycle control and cancer

J Bartek  1 , J Bartkova, J Lukas
Affiliations
Review

The retinoblastoma protein pathway in cell cycle control and cancer

J Bartek et al. Exp Cell Res. .

Abstract

Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources