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. 1976 Feb;6(1-3):135-42.
doi: 10.1007/BF01972197.

Effect of a cholesterol-rich diet on cholesterol content and phagocytic activity of rat macrophages

F Feo, R A Canuto, M V Torrielli, R Garcea, M U Dianzani

Effect of a cholesterol-rich diet on cholesterol content and phagocytic activity of rat macrophages

F Feo et al. Agents Actions. 1976 Feb.

Abstract

Treatment for 11-13 weeks with a cholesterol-rich diet induced increases in free and esterified serum cholesterol. There was also an increase in free cholesterol of peritoneal macrophages. A 2.2 times rise in the cholesterol to phospholipid ratio of plasma membranes occurred in cholesterol-enriched macrophages. No changes were observed in phagolysosomes. Cholesterol-enriched macrophages showed a 35.8% inhibition of latex particles phagocytosis. When lipid droplets were substituted for latex the inhibition was 81.7%.

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