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Comparative Study
. 1976 Feb;6(1-3):320-5.
doi: 10.1007/BF01972249.

Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration

S C Meacock, E A Kitchen
Comparative Study

Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration

S C Meacock et al. Agents Actions. 1976 Feb.

Abstract

The anti-inflammatory properties of 7 non-steroidal drugs have been examined in two animal models and one in vitro system. The models used were (1) carrageenin-induced paw oedema in rats previously depleted of polymorphonuclear cells, (2) carrageenin-induced rat pleurisy and (3) migration of rat peritoneal leucocytes from glass capillary tubes in vitro. All of the drugs suppressed oedema formation in rats depleted of polymorphonuclear cells. None affected the migration of polymorphonuclear cells into the inflamed pleural cavity. Four drugs suppressed the migration of mononuclear cells in the latter model. Of these, only phenylbutazone and indomethacin suppressed the random migration of leucocytes in vitro. It was concluded that the suppression of mononuclear cell migration is not a general property of non-steroidal anti-inflammatory drugs.

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References

    1. J Pharm Pharmacol. 1972 Jul;24(7):575-7 - PubMed
    1. J Pharm Pharmacol. 1971 Apr;23 (4):297-8 - PubMed
    1. J Immunol. 1964 Aug;93:264-73 - PubMed
    1. J Pathol. 1971 Dec;105(4):239-56 - PubMed
    1. J Pathol. 1973 Feb;109(2):151-61 - PubMed

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