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Review
. 1998 Jan 6;95(1):85-6.
doi: 10.1073/pnas.95.1.85.

Controlling cell cycle and cell fate: common strategies in prokaryotes and eukaryotes

A Amon  1
Affiliations
Review

Controlling cell cycle and cell fate: common strategies in prokaryotes and eukaryotes

A Amon. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Comparison of the temporal and spatial localization of CtrAp, Sic1p, and Ash1p. (A) To facilitate the comparison of CtrA accumulation with that of Sic1, the nomenclature of the eukaryotic cell cycle has been adapted. CtrA protein is present in replication incompetent swarmer cells (“G1”), where it inhibits the initiation of DNA replication. At the swarmer cell–stalked cell transition, CtrA is degraded and the cell initiates DNA replication. CtrA protein then accumulates during S phase, where it is uniformly distributed throughout the predivisional cell. Shortly before or at the time of chromosome partitioning and cell division, CtrA is cleared from the stalked cell but remains present in the swarmer cell portion of the predivisional cell. CtrA protein then persists in the swarmer cell. (B) Sic1 protein is present in G1 cells, where it inhibits cyclin-dependent kinases that trigger initiation of DNA replication. At the G1–S phase transition, Sic1 protein is degraded, allowing entry into S phase. The protein is absent throughout S phase and early mitosis, but accumulates during late mitosis. The protein then persists throughout the following G1 period. Because the localization of Sic1 within the cell is not known, the protein has been drawn to be distributed throughout the cell. (C) Ash1, like CtrA, is asymmetrically distributed between mother and daughter cells at the end of mitosis. Ash1 protein is absent in early stages of the cell cycle but accumulates toward the end of mitosis in the bud, the future daughter cell. It persists in the daughter cell throughout the G1 phase, inhibiting transcription of the HO endonuclease thereby preventing mating-type switching. As this daughter cell undergoes a new cell cycle, Ash1 protein is degraded. By the following G1 phase, when the daughter cell has become a mother cell, Ash1 protein has been eliminated, allowing the cell to switch its mating type.
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References

    1. Quon K C, Yang B, Domian I J, Shapiro L, Marczynski G T. Proc Natl Acad Sci USA. 1998;95:120–125. - PMC - PubMed
    1. Brun Y V, Marczynski G, Shapiro L. Annu Rev Biochem. 1994;63:419–450. - PubMed
    1. Quon K C, Marczynski G T, Shapiro L. Cell. 1996;84:83–93. - PubMed
    1. Domian I J, Quon K C, Shapiro L. Cell. 1997;90:415–424. - PubMed
    1. Nigg E A. BioEssays. 1995;17:471–480. - PubMed

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