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Comment
. 1998 Jan;72(1):886-7.

Genetic drift of human immunodeficiency virus type 1?

E C Holmes, P M de A Zanotto
Comment

Genetic drift of human immunodeficiency virus type 1?

E C Holmes et al. J Virol. 1998 Jan.
No abstract available

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Figures

FIG. 1
FIG. 1
Spatial distribution of amino acid variability in 51 HIV-1 subtype B nef protein sequences extracted from the Los Alamos HIV database (3). Variability is plotted as the percent normalized index of variation (v%) obtained according to the following formula: v% = [(RD/N)100], where RD is the raw diversity, i.e., the number of distinct character states (20 amino acids plus 1 for gaps) observed at an amino acid site divided by the total number of sequences (51), and N (0.412) is the maximum possible diversity per site (21/51). For ease of analysis, two regions of high variability due to frequent insertion and deletion events were removed (codons 24 to 39 and 78 to 85). Sequences with stop or ambiguous codons were not included in the analysis.
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References

    1. Hughes A L, Nei M. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature. 1988;335:367–370. - PubMed
    1. Kimura M. The neutral theory of molecular evolution. Cambridge, United Kingdom: Cambridge University Press; 1983.
    1. Myers G, Korber B, Foley B, Jeang K-T, Mellors J W, Wain-Hobson S. Human retroviruses and AIDS 1996. Los Alamos, N.M: Los Alamos National Laboratory; 1996.
    1. Nei M. Molecular evolutionary genetics. New York, N.Y: Columbia University Press; 1987.
    1. Plikat U, Nieselt-Struwe K, Meyerhans A. Genetic drift can dominate short-term human immunodeficiency virus type 1 nefquasispecies in vivo. J Virol. 1997;71:4233–4240. - PMC - PubMed

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