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. 1998 Jan 9;279(5348):237-42.
doi: 10.1126/science.279.5348.237.

Functional expression of a mammalian odorant receptor

H Zhao  1 , L Ivic, J M Otaki, M Hashimoto, K Mikoshiba, S Firestein
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Functional expression of a mammalian odorant receptor

H Zhao et al. Science. .

Abstract

Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.

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  • Opening the window to odor space.
    Reed RR. Reed RR. Science. 1998 Jan 9;279(5348):193. doi: 10.1126/science.279.5348.193. Science. 1998. PMID: 9446227 No abstract available.

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