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. 1976 Mar 1;153(3):729-32.
doi: 10.1042/bj1530729.

The prediction of the conformation of membrane proteins from the sequence of amino acids

N M Green, M T Flanagan

The prediction of the conformation of membrane proteins from the sequence of amino acids

N M Green et al. Biochem J. .

Abstract

The methods of Chou & Fasman [Biochemistry (1974) 13, 211-222, 222-245] and of Lim [J. Mol. Biol. (1974)88, 857-872, 873-894] for predicting secondary structure from amino acid sequence have been applied to five predominantly helical membrane-associated peptides. The predictions from the method of Lim (1974a,b) are consistent with the experimental observations, whereas those from Chou & Fasman (1974a,b), although not inconsistent with alpha-helix, favour a beta-structure for several very hydrophobic regions. The results may be rationalized in terms of the effect of the solvent on the conformation of a polypeptide.

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