Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Mar 1;153(3):737-9.
doi: 10.1042/bj1530737.

Inactivation of cathepsin D by dithiophosgene and by 2,2-dichloro-1,3-dithiacyclobutanone

E T Rakitzis, T B Malliopoulou

Inactivation of cathepsin D by dithiophosgene and by 2,2-dichloro-1,3-dithiacyclobutanone

E T Rakitzis et al. Biochem J. .

Abstract

Cathepsin D, purified from bovine spleen, is inactivated by the unstable inhibitors dithiophosgene and 2,2-dichloro-1,3-dithiacyclobutanone. Inhibition constants are identical for both of the compounds tested: Ki 96.1 muM;k/c0.406. It appears that the active species is 2,2-dichloro-1,3-dithiacyclobutanone, to which dithiophosgene is hydrolysed before cathepsin D inactivation.

PubMed Disclaimer

References

    1. Ann N Y Acad Sci. 1958 Apr 24;68(3):663-8 - PubMed
    1. Biochem J. 1974 Aug;141(2):601-3 - PubMed
    1. Eur J Biochem. 1974 Oct 1;48(1):245-54 - PubMed