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. 1998 Jan;66(1):361-3.
doi: 10.1128/IAI.66.1.361-363.1998.

Extensive immunoglobulin binding of Plasmodium falciparum-infected erythrocytes in a group of children with moderate anemia

C Scholander  1 , J Carlson, P G Kremsner, M Wahlgren
Affiliations

Extensive immunoglobulin binding of Plasmodium falciparum-infected erythrocytes in a group of children with moderate anemia

C Scholander et al. Infect Immun. 1998 Jan.

Abstract

Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum-infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.

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Figures

FIG. 1
FIG. 1
Ig binding and rosetting of P. falciparum-infected erythrocytes from 207 fresh parasite isolates. Each symbol represents one isolate. ○, isolates binding IgM alone; □, isolates binding IgG alone; •, isolates binding both Igs.
FIG. 2
FIG. 2
Ig binding of P. falciparum-infected erythrocytes in 207 fresh parasite isolates from a group of children with moderate anemia (Hb, >50 to ≤90 g/liter; n = 73) and a group of children without anemia (Hb, >90 g/liter; n = 134). Each symbol represents one isolate.
See this image and copyright information in PMC

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