Review
doi: 10.1016/s0955-0674(97)80078-6.
TOR signalling and control of cell growth
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- PMID: 9425342
- DOI: 10.1016/s0955-0674(97)80078-6
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Review
TOR signalling and control of cell growth
Curr Opin Cell Biol.
1997 Dec.
Abstract
TOR, phosphatidylinositol 3-kinase, p70s6k, and 4E-BP1 have recently emerged as components of a major signalling pathway that is dedicated to protein translation and thus to cell growth. This pathway appears to be conserved, at least in part, in yeast, slime molds, plants, flies, and mammals. TOR and phosphatidylinositol 3-kinase control p70s6k and 4E-BP1, which, in turn, directly control the translation initiation machinery.
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