doi: 10.1016/s0378-1119(97)00511-8.
Introns enable the polyomavirus middle and small T antigens to stimulate the growth of primary rat embryo fibroblasts
Affiliations
- PMID: 9426248
- DOI: 10.1016/s0378-1119(97)00511-8
Item in Clipboard
Introns enable the polyomavirus middle and small T antigens to stimulate the growth of primary rat embryo fibroblasts
Gene.
.
Abstract
We constructed spliceable vectors that separately encode polyomavirus MT and ST. The addition of an intron enables MT to transform and to immortalize more efficiently and ST to transiently stimulate the growth of primary rat embryo fibroblasts.
Similar articles
-
Polyomavirus large T antigen zinc finger is not required for efficient cellular immortalization of primary rat embryo fibroblasts.Virus Res. 1996 Dec;46(1-2):171-5. doi: 10.1016/s0168-1702(96)01382-2. Virus Res. 1996. PMID: 9029789
-
Glucocorticoids facilitate the stable transformation of embryonal rat fibroblasts by a polyomavirus large tumor antigen-deficient mutant.Proc Natl Acad Sci U S A. 1988 Aug;85(15):5571-5. doi: 10.1073/pnas.85.15.5571. Proc Natl Acad Sci U S A. 1988. PMID: 2840668 Free PMC article.
-
Transformation by hamster polyomavirus: identification and functional analysis of the early genes.J Virol. 1992 Apr;66(4):2495-504. doi: 10.1128/JVI.66.4.2495-2504.1992. J Virol. 1992. PMID: 1312640 Free PMC article.
-
Mechanisms of cell transformation induced by polyomavirus.Braz J Med Biol Res. 1999 Jul;32(7):861-5. doi: 10.1590/s0100-879x1999000700010. Braz J Med Biol Res. 1999. PMID: 10454745 Review.
-
Gene expression and genetic engineering in the lens. Friedenwald lecture.Invest Ophthalmol Vis Sci. 1987 Jan;28(1):9-28. Invest Ophthalmol Vis Sci. 1987. PMID: 3026987 Review. No abstract available.
Cited by
-
Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.Mol Cell Biol. 1998 Dec;18(12):7556-64. doi: 10.1128/MCB.18.12.7556. Mol Cell Biol. 1998. PMID: 9819441 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
