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. 1976 Jan;12(1):31-6.
doi: 10.1007/BF02832790.

Regulation by calcium of the proliferation of heart cells from young adult rats

S H Swierenga, J P MacManus, J F Whitfield

Regulation by calcium of the proliferation of heart cells from young adult rats

S H Swierenga et al. In Vitro. 1976 Jan.

Abstract

Cells of primary and secondary cultures of rat heart ventricle were grown in a medium supplemented with homologous plasma to avoid the non-specific proliferogenic effects of foreign sera. Specific chelation of calcium from the medium arrested the cells' progression through their cycle at the G1 phase. A permanent or brief restoration of the extracellular calcium level (48 hr later) was followed, after a 5 to 6 hr delay, by a burst of DNA synthesis, and the resumption of mitotic activity.

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