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. 1997 Dec 1;418(3):315-8.
doi: 10.1016/s0014-5793(97)01372-0.

Promoter structure of the MxA gene that confers resistance to influenza virus

K Nakade  1 , H Handa, K Nagata
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Free article

Promoter structure of the MxA gene that confers resistance to influenza virus

K Nakade et al. FEBS Lett. .
Free article

Abstract

The human MxA protein is one of the interferon-inducible proteins that inhibits multiplication of influenza virus and other viruses. To clarify the control mechanism of its expression, we prepared a series of mutant MxA promoters and identified a 30 nucleotides long cis-acting interferon-responsive element by transient transfection assay. Its nucleotide sequence is somewhat similar to that of ISRE (interferon-stimulated response element), suggesting that the regulation of MxA mRNA synthesis is under the control of some ISRE binding factor such as ISGF-3 (interferon-stimulated gene factor-3).

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