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. 1997 Dec;15(12 Pt 1):1385-8.
doi: 10.1097/00004872-199715120-00003.

A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension

S Schmidt  1 , J Beige, M Walla-Friedel, M C Michel, A M Sharma, E Ritz
Affiliations

A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension

S Schmidt et al. J Hypertens. 1997 Dec.

Abstract

Background: A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension.

Objective: To determine whether this observation could be confirmed with a different population sample.

Design: We examined 414 individuals with primary hypertension and 172 normotensive controls.

Methods: The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction.

Conclusions: We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.

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