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. 1998 Jan;36(1):6-10.
doi: 10.1128/JCM.36.1.6-10.1998.

Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993

M Kuzuya  1 , R Fujii, M Hamano, M Yamada, K Shinozaki, A Sasagawa, S Hasegawa, H Kawamoto, K Matsumoto, A Kawamoto, A Itagaki, S Funatsumaru, S Urasawa
Affiliations

Survey of human group C rotaviruses in Japan during the winter of 1992 to 1993

M Kuzuya et al. J Clin Microbiol. 1998 Jan.

Abstract

Fecal specimens from patients with acute diarrhea were collected from 10 prefectures in Japan over a 6-month period (November 1992 to April 1993), and the specimens that were negative for human group A rotaviruses were screened for the presence of human group C rotaviruses (CHRVs) by the reverse passive hemagglutination test. Of 784 specimens examined, 53 samples (6.8%) that were collected in 7 of 10 prefectures were positive for CHRV, indicating that CHRVs are widely distributed across Japan. Most of the CHRV isolates were detected in March and April, and CHRVs mainly prevailed in children ages 3 to 8 years. The genome electropherotypes of eight strains isolated in five individual prefectures were surprisingly similar to each other and were different from those of CHRV strains isolated to date. The outer capsid glycoprotein (VP7) gene homologies of the isolates retrieved in 1993 were subsequently analyzed by the dot blot hybridization method. As a result, the VP7 genes of the isolates revealed very high levels of homology not only with each other but also with the VP7 gene of the OK118 strain isolated in 1988. These results suggest that a large-scale outbreak of CHRV occurred during the winter of 1992 and 1993 in Japan.

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Figures

FIG. 1
FIG. 1
Map of Japan showing the prefectures from which the fecal specimens were collected. Darker shading indicates the prefectures in which CHRVs have been detected. A, Chiba; B, Niigata; C, Toyama; D, Gifu; E, Fukui; F, Tottori; G, Okayama; H, Kagawa; I, Shimane; J, Saga.
FIG. 2
FIG. 2
Comparison of genome electropherotypes of CHRV field isolates. Lanes: 1, 93K332 strain (Chiba isolate); 2, 93K360 strain (Chiba isolate); 3, F522 strain (Fukui isolate); 4, 34803 strain (Tottori isolate); 5, T360 strain (Okayama isolate); 6, K9304 strain (Okayama isolate); 7, 93-48 strain (Saga isolate); 8, 93-42 strain (Saga isolate); 9, OK118 strain, which exhibits the pattern I electropherotype; 10, K9304 strain; 11, OK450 strain, which exhibits the pattern II electropherotype.
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