Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies
- PMID: 9431971
- PMCID: PMC124858
- DOI: 10.1128/JCM.36.1.294-295.1998
Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies
Abstract
A new commercial glycoprotein G-based enzyme immunoassay (gG-EIA) was compared with Western blotting (WB) for detection of herpes simplex virus type 1 (HSV-1) or HSV-2 type-specific antibodies in 193 serum samples. Sensitivity for HSV-1 was 95%; specificity was 96%. Sensitivity for HSV-2 was 98%; specificity was 97%. Twelve of 13 serum samples with equivocal gG-EIA results were serotyped by WB.
References
-
- Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. Ann Intern Med. 1991;115:520–526. - PubMed
-
- Ashley R L. Current concepts of laboratory diagnosis of herpes simplex infection. In: Sacks S L, Straus S E, Whitley R J, Griffiths P D, editors. Clinical management of herpes viruses. Washington, D.C: IOS Press; 1995. pp. 137–171.
-
- Brown Z A, Selke S, Zeh J, Kopelman J, Maslow A, Ashley R L, Watts H, Berry S, Herd M, Corey L. The acquisition of herpes simplex virus during pregnancy. N Engl J Med. 1997;337:509–515. - PubMed
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