Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1997;14(6):1097-100.
doi: 10.1002/(SICI)1098-2272(1997)14:6<1097::AID-GEPI89>3.0.CO;2-C.

Analysis of two-locus traits under heterogeneity for recessive versus dominant inheritance

S M Leal  1 , J Ott
Affiliations
Clinical Trial

Analysis of two-locus traits under heterogeneity for recessive versus dominant inheritance

S M Leal et al. Genet Epidemiol. 1997.

Abstract

Complex traits have been modeled under various modes of two-locus inheritance. One example of a two-locus threshold model is the situation where an individual is susceptible to a disease trait if he or she carries three or more disease alleles. Under this model, if each locus is examined individually the inheritance appears recessive for some mating types and dominant for others. We developed a heterogeneity test, the Model-heterogeneity test, where an admixture of dominant and recessive sibships can be present. The properties of the Model-heterogeneity test were examined and compared to the Admixture test. The power of the Model-heterogeneity test to detect linkage is comparable to that of the Admixture test.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JI Jr., Gershon ES (1994): Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene. Proc Natl Acad Sci USA 91:5918–5921. - PMC - PubMed
    1. Clerget-Darpoux F, Bonaiti-Pellie C, Hochez J (1986): Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393–399. - PubMed
    1. Lathrop GM, Lalouel JM, Julier C, Ott J (1984): Strategies for multilocus linkage analysis in humans. ProcNatl Acad Sci USA 81:3443–3446. - PMC - PubMed
    1. Newman RJ, Rice JP (1992): Two-locus models of disease. Genet Epidemiol 9:347–365. - PubMed
    1. Ott J (1983): Linkage analysis and family classification under heterogeneity. Ann Hum Genet 47:311–320. - PubMed

Publication types

LinkOut - more resources