Review
doi: 10.1016/s0959-440x(97)80156-x.
T-cell receptor structure and TCR complexes
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- PMID: 9434905
- DOI: 10.1016/s0959-440x(97)80156-x
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Review
T-cell receptor structure and TCR complexes
Curr Opin Struct Biol.
1997 Dec.
Erratum in
- Curr Opin Struct Biol 1998 Feb;8(1):124-5
Abstract
The first crystal structures of intact T-cell receptors (TCRs) and their complexes with MHC peptide antigens (pMHC) were reported during the past year, along with those of a single-chain TCR Fv fragment and a beta-chain complexed with two different bacterial superantigens. These structures have shown the similarities and differences in the architecture of the antigen-binding regions of TCRs and antibodies, and how the TCR interacts with pMHC ligands as well as with superantigens.
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