Cyclooxygenase-2 in rat nephron development
- PMID: 9435689
- DOI: 10.1152/ajprenal.1997.273.6.F994
Cyclooxygenase-2 in rat nephron development
Abstract
The inducible second isoform of cyclooxygenase (COX-2) that mediates inflammation also is expressed at low levels in normal adult rat kidneys and is upregulated in response to noninflammatory stimuli (R. C. Harris, J. A. McKanna, Y. Akai, H. R. Jacobson, R. N. DuBois, and M. D. Breyer, J. Clin. Invest. 94: 2504-2510, 1994). Roles in morphogenesis are indicated by reported teratogenicity of COX inhibitors and renal dysgenesis in COX-2 knockout mice (J. E. Dinchuk, B. D. Car, R. J. Focht, J. J. Johnston, B. D. Jaffee, M. B. Covington, N. R. Contel, V. M. Eng, R. J. Collins, P. M. Czerniak, A. G. Stewart, and J. M. Trzaskos, Nature 378: 406-409, 1995; S. G. Morham, R. Lagenbach, C. D. Loftin, H. F. Tiano, N. Vouloumanos, J. C. Jennette, J. F. Mahler, K. D. Kluckman, A. Ledford, C. A. Lee, and O. Smithies. Cell 83: 473-482, 1995). Blots from developing rat kidneys demonstrated that COX-2 mRNA and immunoreactive protein were present in neonates, peaked in the 2nd and 3rd postnatal weeks and declined to adult levels by the 3rd month. Immunolocalization and in situ hybridization detected intense COX-2 immunoreactivity and mRNA in a subset of thick ascending limb epithelial cells near the macula densa in each developing nephron; after 2 wk the COX-2 gradually waned. These data demonstrate that COX-2 expression is subject to normal developmental regulation and can be sustained over extended periods; they also support the conclusion that metabolites of COX-2 play important roles in the differentiation and early functions of mammalian nephrons.
Similar articles
-
Low endogenous glucocorticoid allows induction of kidney cortical cyclooxygenase-2 during postnatal rat development.Am J Physiol Renal Physiol. 2004 Jan;286(1):F26-37. doi: 10.1152/ajprenal.00099.2003. Epub 2003 Sep 16. Am J Physiol Renal Physiol. 2004. PMID: 13129852
-
Regulation of cyclooxygenase expression in the kidney by dietary salt intake.Am J Physiol. 1998 Mar;274(3):F481-9. doi: 10.1152/ajprenal.1998.274.3.F481. Am J Physiol. 1998. PMID: 9530264
-
Selective increase of cyclooxygenase-2 expression in a model of renal ablation.Am J Physiol. 1998 Oct;275(4):F613-22. doi: 10.1152/ajprenal.1998.275.4.F613. Am J Physiol. 1998. PMID: 9755133
-
Physiological regulation of cyclooxygenase-2 in the kidney.Am J Physiol Renal Physiol. 2001 Jul;281(1):F1-11. doi: 10.1152/ajprenal.2001.281.1.F1. Am J Physiol Renal Physiol. 2001. PMID: 11399641 Review.
-
Cyclooxygenase-2 and the renal renin-angiotensin system.Acta Physiol Scand. 2004 Aug;181(4):543-7. doi: 10.1111/j.1365-201X.2004.01329.x. Acta Physiol Scand. 2004. PMID: 15283769 Review.
Cited by
-
Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs.J Vet Med Sci. 2021 May 17;83(5):837-840. doi: 10.1292/jvms.21-0074. Epub 2021 Apr 5. J Vet Med Sci. 2021. PMID: 33814522 Free PMC article.
-
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.Diabetes. 2018 Sep;67(9):1847-1857. doi: 10.2337/db17-1513. Epub 2018 Jun 29. Diabetes. 2018. PMID: 29959129 Free PMC article.
-
Angiotensin II attenuates renal cortical cyclooxygenase-2 expression.J Clin Invest. 1999 Apr;103(7):953-61. doi: 10.1172/JCI5505. J Clin Invest. 1999. PMID: 10194467 Free PMC article.
-
Increased Risk of End-Stage Renal Disease (ESRD) Requiring Chronic Dialysis is Associated With Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Nationwide Case-Crossover Study.Medicine (Baltimore). 2015 Sep;94(38):e1362. doi: 10.1097/MD.0000000000001362. Medicine (Baltimore). 2015. PMID: 26402800 Free PMC article.
-
Immunohistochemical Expressions of Main PGE(2) Biosynthesis-related Enzymes and PGE(2) Receptor in Rat Nephrogenesis.J Toxicol Pathol. 2011 Dec;24(4):257-61. doi: 10.1293/tox.24.257. Epub 2012 Jan 7. J Toxicol Pathol. 2011. PMID: 22319240 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials