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. 1998 Jan;5(1):55-9.
doi: 10.1038/nsb0198-55.

Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain

M Akke  1 , J Liu, J Cavanagh, H P Erickson, A G Palmer 3rd
Affiliations

Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain

M Akke et al. Nat Struct Biol. 1998 Jan.

Abstract

A novel off-resonance rotating-frame 15N NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 microseconds in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the beta-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the beta-sheets. Flexibility of the loop containing the Arg-Gly-Asp (RGD) tripeptide may affect the accessibility of this motif in protein-protein interactions.

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