Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997;45(5-6):475-8.

Interferon alpha reduces the level of radiation-induced micronuclei in mouse bone marrow cells

L Fomenko  1 , N Sirota, V Ravin, A Gaziev
Affiliations
  • PMID: 9437506

Interferon alpha reduces the level of radiation-induced micronuclei in mouse bone marrow cells

L Fomenko et al. Arch Immunol Ther Exp (Warsz). 1997.

Abstract

The effect of natural mouse interferon alpha (IFN-alpha) on production of micronuclei (MN) in bone marrow cells of whole-body gamma-irradiated mice (in sublethal dose of 0.5 Gy from 60Co source) was studied. It was shown that free interferon alpha (IFN-alpha(F)) and IFN-alpha encapsulated into liposomes (IFN-alpha(L)), when injected intraperitoneally to mice prior to their irradiation, reduced substantially the frequency of gamma-ray-induced micronuclei in polychromatic erythrocytes (MN-PCE) of the bone marrow of these mice. The antimutagenic effect of IFN-alpha(F), as registered by the micronucleus test, was observed in bone marrow cells of mice irradiated 24 h after injection. For IFN-alpha(L), the decrease in MN frequency in PCE of mice was observed 48-72 h after administration of the preparation.

PubMed Disclaimer

Publication types