Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Jan 23;279(5350):563-6.
doi: 10.1126/science.279.5350.563.

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

J M Chan  1 , M J Stampfer, E Giovannucci, P H Gann, J Ma, P Wilkinson, C H Hennekens, M Pollak
Affiliations

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

J M Chan et al. Science. .

Abstract

Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.

PubMed Disclaimer

Comment in

Publication types

MeSH terms

Substances