Review
doi: 10.1016/s0969-2126(97)00304-3.
Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors
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- PMID: 9438871
- DOI: 10.1016/s0969-2126(97)00304-3
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Review
Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors
Structure.
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Abstract
Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.
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