Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997;16(4):355-74.
doi: 10.1007/BF02786399.

Protein kinase C in IL-2 signal transduction

Y Lu  1 , J P Durkin
Affiliations
Review

Protein kinase C in IL-2 signal transduction

Y Lu et al. Immunol Res. 1997.

Abstract

Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracellular signals coupled to the IL-2 receptor and responsible for mediating IL-2 effects in T-cells is far less developed, and the role that protein kinase C (PKC) may play in the various cellular responses to IL-2 receptor activation is unclear. In this article we will discuss IL-2, its receptors, and IL-2 signal transduction in relation to the physiological roles PKC activation may play in IL-2-mediated activation of T-cells and other hematopoietic cells.

PubMed Disclaimer

References

    1. Annu Rev Immunol. 1992;10:295-331 - PubMed
    1. Science. 1992 Jul 17;257(5068):379-82 - PubMed
    1. Cell. 1992 Jul 10;70(1):57-67 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(24):9694-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2674-8 - PubMed