Review
doi: 10.1023/a:1005841206252.
Neurotrophins in cerebellar granule cell development and medulloblastoma
Affiliations
- PMID: 9440031
- DOI: 10.1023/a:1005841206252
Item in Clipboard
Review
Neurotrophins in cerebellar granule cell development and medulloblastoma
J Neurooncol.
1997 Dec.
Abstract
Medulloblastomas may be derived from granule cells of the developing cerebellum. Children with tumors expressing high levels of the neurotrophin-3 receptor, TrkC, have a more favorable outcome. During development, TrkC is expressed in the most mature granule cells. Favorable medulloblastomas may be derived from more highly differentiated granule cells.
Similar articles
-
Growth factor receptors and medulloblastoma.J Neurooncol. 1996 Jul;29(1):85-9. doi: 10.1007/BF00165521. J Neurooncol. 1996. PMID: 8817419 Review.
-
Constitutive phosphorylation of TrkC receptors in cultured cerebellar granule neurons might be responsible for the inability of NT-3 to increase neuronal survival and to activate p21 Ras.Neurochem Res. 1996 Jul;21(7):851-9. doi: 10.1007/BF02532309. Neurochem Res. 1996. PMID: 8873090
-
Eradication of cerebellar granular cells alters the developmental expression of trk receptors in the rat inferior olive.Int J Dev Neurosci. 1998 Feb;16(1):49-62. doi: 10.1016/s0736-5748(98)00004-5. Int J Dev Neurosci. 1998. PMID: 9664222
-
Induction of TrkA receptor by retinoic acid in leukaemia cell lines.Neuroreport. 1997 Mar 24;8(5):1067-70. doi: 10.1097/00001756-199703240-00001. Neuroreport. 1997. PMID: 9175086
-
Neurotrophin signal transduction in medulloblastoma.J Neurosci Res. 1997 Sep 1;49(5):522-7. doi: 10.1002/(SICI)1097-4547(19970901)49:5<522::AID-JNR2>3.0.CO;2-D. J Neurosci Res. 1997. PMID: 9302073 Review.
Cited by
-
Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response.Childs Nerv Syst. 2017 Sep;33(9):1463-1471. doi: 10.1007/s00381-017-3506-y. Epub 2017 Jul 10. Childs Nerv Syst. 2017. PMID: 28695340
-
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.Cancer Cell. 2008 Aug 12;14(2):135-45. doi: 10.1016/j.ccr.2008.07.003. Cancer Cell. 2008. PMID: 18691548 Free PMC article.
-
Expression of p75NTR in fetal brain and medulloblastomas: evidence of a precursor cell marker and its persistence in neoplasia.J Neurooncol. 2009 Apr;92(2):193-201. doi: 10.1007/s11060-008-9755-6. Epub 2008 Dec 9. J Neurooncol. 2009. PMID: 19066726
-
Brain cancer propagating cells: biology, genetics and targeted therapies.Trends Mol Med. 2009 Nov;15(11):519-30. doi: 10.1016/j.molmed.2009.09.003. Epub 2009 Nov 2. Trends Mol Med. 2009. PMID: 19889578 Free PMC article. Review.
-
Emerging treatments and gene expression profiling in high-risk medulloblastoma.Paediatr Drugs. 2007;9(2):81-96. doi: 10.2165/00148581-200709020-00002. Paediatr Drugs. 2007. PMID: 17407364 Review.