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Review
. 1997 Dec;35(3):347-52.
doi: 10.1023/a:1005841206252.

Neurotrophins in cerebellar granule cell development and medulloblastoma

S L Pomeroy  1 , M E Sutton, L C Goumnerova, R A Segal
Affiliations
Review

Neurotrophins in cerebellar granule cell development and medulloblastoma

S L Pomeroy et al. J Neurooncol. 1997 Dec.

Abstract

Medulloblastomas may be derived from granule cells of the developing cerebellum. Children with tumors expressing high levels of the neurotrophin-3 receptor, TrkC, have a more favorable outcome. During development, TrkC is expressed in the most mature granule cells. Favorable medulloblastomas may be derived from more highly differentiated granule cells.

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