[Systemic rheumatoid arthritis]

Abstract

The term systemic rheumatoid disease refers to patients with rheumatoid arthritis who have clinical or histological evidence of vasculitis or serositis, or both. Males are affected more often than females, and vasculitis may develop in almost any organ. Rheumatoid nodules, joint deformities and erosions are often present, even though the arthritis may be inactive. The condition is associated with high titers of IgG rheumatoid factor. An intermittent bolus regimen of cyclophosphamide and corticosteroids appears to be effective. Two patients with systemic rheumatoid arthritis are presented.