Minimum effective doses of mebendazole in treatment of soil-transmitted helminths
- PMID: 9444014
Minimum effective doses of mebendazole in treatment of soil-transmitted helminths
Abstract
Three hundred and fifteen primary school children infected with soil-transmitted helminths were divided into 5 groups. Three groups were treated with 25, 50 and 75 mg mebendazole (MBZ) single dose. One group was given MBZ conventional dose of 100 mg twice daily for 3 days and another group was given albendazole (ABZ) standard dose of 400 mg single dose. Every trial lower MBZ dose 75 mg, 50 mg and 25 mg regimen were highly effective against Ascaris lumbricoides but only moderately effective against Trichuris trichiura and Necator americanus.
Similar articles
-
Oxantel pamoate-albendazole for Trichuris trichiura infection.N Engl J Med. 2014 Feb 13;370(7):610-20. doi: 10.1056/NEJMoa1301956. N Engl J Med. 2014. PMID: 24521107 Clinical Trial.
-
Efficacy and Safety of a Single-Dose Mebendazole 500 mg Chewable, Rapidly-Disintegrating Tablet for Ascaris lumbricoides and Trichuris trichiura Infection Treatment in Pediatric Patients: A Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study.Am J Trop Med Hyg. 2017 Dec;97(6):1851-1856. doi: 10.4269/ajtmh.17-0108. Epub 2017 Aug 31. Am J Trop Med Hyg. 2017. PMID: 29016336 Free PMC article. Clinical Trial.
-
Flubendazole in the treatment of Ascaris lumbricoides and Trichuris trichiura: a comparison of two different regimens with single-dose.Ceylon Med J. 1984 Dec;29(4):199-203. Ceylon Med J. 1984. PMID: 6543679 No abstract available.
-
Reducing intestinal nematode infection: efficacy of albendazole and mebendazole.Parasitol Today. 2000 Feb;16(2):71-4. doi: 10.1016/s0169-4758(99)01544-6. Parasitol Today. 2000. PMID: 10652492 Review.
-
Efficacy of single-dose 500 mg mebendazole in soil-transmitted helminth infections: a review.J Helminthol. 2018 May;92(3):269-278. doi: 10.1017/S0022149X17000426. Epub 2017 Jul 18. J Helminthol. 2018. PMID: 28716158 Review.
Cited by
-
An Update on the Geohelminths: Ascaris lumbricoides, Hookworms, Trichuris trichiura, and Strongyloides stercoralis.Curr Infect Dis Rep. 2002 Feb;4(1):59-64. doi: 10.1007/s11908-002-0068-1. Curr Infect Dis Rep. 2002. PMID: 11853658
-
Anthelmintic drugs for treating ascariasis.Cochrane Database Syst Rev. 2020 Apr 14;4(4):CD010599. doi: 10.1002/14651858.CD010599.pub2. Cochrane Database Syst Rev. 2020. PMID: 32289194 Free PMC article.