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Review
. 1997;51(4):421-30.

[Tissue factor pathway inhibitor (TFPI) and its role in pathology]

[Article in Polish]
M Rucińska  1 , M Gacko, Z Skrzydlewski
Affiliations
  • PMID: 9446103
Review

[Tissue factor pathway inhibitor (TFPI) and its role in pathology]

[Article in Polish]
M Rucińska et al. Postepy Hig Med Dosw. 1997.

Abstract

Tissue factor pathway inhibitor (TFPI) is an important regulator of blood coagulation. It was described as antyconwertin (AC), extrinsic pathway inhibitor (EPI) and lipoprotein-associated coagulation inhibitor (LACI). TFPI is a glycoprotein, which is mainly synthesized by vascular endothelial cells. The concentration of this enzyme in plasma is low (100 ng/ml). TFPI inhibits activity of factor Xa and complex FVIIa/TF. Changes TFPI activity play an important role in coagulation disorders and presently the function of TFPI in various kinds of diseases is discussed.

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