Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Nov;14(10):558-61.
doi: 10.1023/a:1022520415915.

Short-term GnRH-analogue administration in patients with PCOS and its impact on hemodynamics and hormonal profile

E Vrtacnik-Bokal  1 , H Meden-Vrtovec
Affiliations

Short-term GnRH-analogue administration in patients with PCOS and its impact on hemodynamics and hormonal profile

E Vrtacnik-Bokal et al. J Assist Reprod Genet. 1997 Nov.

Abstract

Purpose: The ovarian response to 14 days of GnRH-analogue (GnRHa) application in patients with polycystic ovary syndrome (PCOS) was evaluated by measuring hemodynamic parameters and hormonal profile.

Methods: Twenty patients with PCOS represented the study group, and 22 patients with normal menstrual cycle (NMC) the reference group. The resistance index (RI) of uteroovarian arterial blood flow and serum level of LH and androstendione were measured on days 4, 13, and 22 of the cycle and after 14 days of GnRHa administration.

Results: On day 22 of the cycle the RI in the uterine artery was 0.86 in the PCOS and 0.82 in the NMC group. Throughout the cycle the ovarian arterial blood flow in both ovaries in the PCOS group was similar to that in inactive ovaries in the NMC group. After the 14-day GnRHa administration the RI of uteroovarian blood flow and the serum level of androstenedione remained unchanged in the PCOS group.

Conclusions: RI in the uteroovarian blood flow and serum androstendione level in the PCOS group are not affected by 14-day GnRHa administration.

PubMed Disclaimer

References

    1. Hata K, Hata T, Senoh D, Makihara K, Aoki S, Takamiya O, Kitao M: Change in ovarian arterial compliance during the human menstrual cycle assessed by Doppler ultrasound. Br J Obstet Gynaecol. 1990;97:163–166. - PubMed
    1. Steer CV, Campbell S, Pampiglione JS, Kingsland CR, Mason BA, Collins WP: Transvaginal colour flow imaging of the uterine arteries during the ovarian and menstrual cycles. Hum Reprod. 1990;5:391–395. - PubMed
    1. Kurjak A, Kupesic-Urek S, Schulman H, Zalud I. Transvaginal color flow Doppler in the assessment of ovarian and uterine blood flow in infertile women. Fertil Steril. 1991;56:870–874. - PubMed
    1. Schurz B, Schon HJ, Wenzl R, Eppel W, Huber J, Reinold E: Endovaginal Doppler flow measurements of the ovarian artery in patients with a normal menstrual cycle and with polycystic ovary syndrome during in vitro fertilization. J Clin Ultrasound. 1993;21:19–25. - PubMed
    1. De Ziegler D, Bessis R, Fanchin R, Frydman R. Transvaginal pulsed and color Doppler in gynecology. Contracept Fertil Sex. 1992;20:1155–1165. - PubMed

MeSH terms

LinkOut - more resources