Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Feb 3;95(3):930-2.
doi: 10.1073/pnas.95.3.930.

The environmental dependency of protein folding best explains prion and amyloid diseases

J W Kelly  1
Affiliations
Review

The environmental dependency of protein folding best explains prion and amyloid diseases

J W Kelly. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Possible pathways for the formation of PrPsc in the sporadic case and in the seeded infectious case, based on the presence of an intermediate that is critical for prion formation.
Figure 2
Figure 2
Prion formation can be inhibited either by ligand binding to PrPc, which shifts the equilibrium toward Prpc under cellular conditions that normally would form the prionogenic intermediate (Upper; also see ref. 35), or by using peptidomimetics that bind to the prionogenic intermediate or other intermediates that precede prion formation (not shown).
See this image and copyright information in PMC

Comment on

References

    1. Prusiner S B. Science. 1997;278:245–251. - PubMed
    1. Huang Z, Prusiner S B, Cohen F E. Curr Top Microbiol Immunol. 1996;207:49–67. - PubMed
    1. Prusiner S B. Trends Biochem Sci. 1996;21:482–487. - PubMed
    1. Kelly J W, Lansbury P T J. Amyloid Int J Exp Clin Invest. 1994;1:186–205.
    1. Kelly J W. Curr Opin Struct Biol. 1996;6:11–17. - PubMed