Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Jan;42(1):94-9.
doi: 10.1128/AAC.42.1.94.

In vitro and in vivo antibacterial activities of S-4661, a new carbapenem

M Tsuji  1 , Y Ishii, A Ohno, S Miyazaki, K Yamaguchi
Affiliations

In vitro and in vivo antibacterial activities of S-4661, a new carbapenem

M Tsuji et al. Antimicrob Agents Chemother. 1998 Jan.

Abstract

The in vitro and in vivo antibacterial activities of S-4661, a new 1beta-methylcarbapenem, were compared with those of imipenem, meropenem, biapenem, cefpirome, and ceftazidime. The activity of S-4661 against methicillin-susceptible staphylococci and streptococci was comparable to that of imipenem, with an MIC at which 90% of the strains tested were inhibited (MIC90) equal to 0.5 microg/ml or less. S-4661 was highly active against members of the family Enterobacteriaceae, Haemophilus influenzae, and Moraxella catarrhalis, with MIC90s ranging from 0.032 to 0.5 microg/ml. Against imipenem-resistant Pseudomonas aeruginosa, S-4661 was the most active among test agents (MIC90, 8 microg/ml). Furthermore, S-4661 displayed a high degree of activity against many ceftazidime-, ciprofloxacin-, and gentamicin-resistant isolates of P. aeruginosa. The in vivo efficacy of S-4661 against experimentally induced infections in mice caused by gram-positive and gram-negative bacteria, including penicillin-resistant Streptococcus pneumoniae and drug-resistant P. aeruginosa, reflected its potent in vitro activity and high levels in plasma in mice. We conclude that S-4661 is a promising new carbapenem for the treatment of infections caused by gram-positive and -negative bacteria, including penicillin-resistant S. pneumoniae and drug-resistant P. aeruginosa.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Chemical structure of S-4661.
See this image and copyright information in PMC

References

    1. Edwards, J. R. 1995. Meropenem: a microbiological overview. J. Antimicrob. Chemother. 36(Suppl. A):1–17. - PubMed
    1. Iso Y, Irie T, Nishino Y, Motokawa K, Nishitani Y. A novel 1β-methylcarbapenem antibiotic, S-4661: synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1β-methlycarbapenems. J Antibiot (Tokyo) 1996;49:199–209. - PubMed
    1. Japanese Society for Chemotherapy. Method for the determination of minimum inhibitory concentration (MIC) of fastidious bacteria and anaerobic bacteria by microdilution method. Chemotherapy (Tokyo) 1993;41:183–189.
    1. Japanese Society for Chemotherapy. Method for the determination of minimum inhibitory concentration (MIC) of aerobic bacteria by microbrothdilution method. Chemotherapy (Tokyo) 1990;38:102–105.
    1. Kahan J S, Kahan F M, Geogelman R, Currie S A, Jacson M, Stapley E O, Miller A K, Hendlin D, Mochales S, Hernandez S, Woodruff H B, Birnbaum J. Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation, and physical properties. J Antibiot (Tokyo) 1979;32:1–12. - PubMed

Publication types

MeSH terms