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Comparative Study
. 1998 Jan;42(1):147-50.
doi: 10.1128/AAC.42.1.147.

KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis

J R Graybill  1 , L K Najvar, A Fothergill, T Hardin, M Rinaldi, C Lambros, S L Regen
Affiliations
Comparative Study

KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis

J R Graybill et al. Antimicrob Agents Chemother. 1998 Jan.

Abstract

KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development.

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Figures

FIG. 1
FIG. 1
Structures of KY-62 and amphotericin B.
See this image and copyright information in PMC

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