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. 1998 Jan;74(1):328-37.
doi: 10.1016/S0006-3495(98)77790-2.

Gramicidin channel kinetics under tension

M Goulian  1 , O N Mesquita, D K Fygenson, C Nielsen, O S Andersen, A Libchaber
Affiliations

Gramicidin channel kinetics under tension

M Goulian et al. Biophys J. 1998 Jan.

Abstract

We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane tension and electrical activity. We find that the dimer formation rate increases by a factor of 5 as tension ranges from 0 to 4 dyn/cm. The dimer lifetime also increases with tension. This behavior is well described by a phenomenological model of membrane elasticity in which tension modulates the mismatch in thickness between the gramicidin dimer and membrane.

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