[The current pathogenetic aspects of MODS in the sepsis patient]

Abstract

MODS, a phenomenon observed in many critically ill patients, is the progressive failure of two or more organ system which results from nonspecific systemic responses to abnormal intravascular inflammation. It is triggered by a number of cellular humoral and biochemical mediators (more than 100). This article takes up the role of individual organ system dysfunction in the development of MODS. Cardiopulmonary, renal and hepatic responses to injury and infection and the relation of these responses to the subsequent development of MODS have been the subject of intense investigations; recently the gastrointestinal tract was identified as another target organ in such patients.