The influence of neuropeptides, serotonin, and interleukin 1beta on temporomandibular joint pain and inflammation
- PMID: 9461143
- DOI: 10.1016/s0278-2391(98)90867-9
The influence of neuropeptides, serotonin, and interleukin 1beta on temporomandibular joint pain and inflammation
Abstract
Purpose: This article describes the possible role of various peptides in producing pain and inflammation in the temporomandibular joint (TMJ).
Material and methods: Current research findings on the spectrophotometric quantification of TMJ synovial fluid for neuropeptide Y (NPY), serotonin (5HT), and interleukin-1beta (IL-1beta) are presented.
Findings: NPY was found in high levels in the synovial fluid of arthritic TMJs with resting pain, and serotonin (5-HT) was found in patients with pain perceived on mandibular movement. These pain-related mediators were also associated with restricted mandibular mobility. Interleukin-1beta (IL-1beta) was found to be strongly associated with hyperalgesia over the TMJ as well as resting pain. Anterior open bite as a clinical sign of joint destruction was found to be associated with high levels of NPY and IL-1beta in the synovial fluid. IL-1beta was also related to the radiographic signs of joint destruction.
Conclusions: Interaction between the peripheral nervous system (sensory and sympathetic nerves) and the immune system is probably of importance for the modulation of pain and inflammation in the TMJ, but this subject has to be investigated further with experimental clinical studies.
Similar articles
-
Neuroendocrine, immune, and local responses related to temporomandibular disorders.J Orofac Pain. 2001 Winter;15(1):9-28. J Orofac Pain. 2001. PMID: 11889652 Review.
-
Interleukin-1beta in synovial fluid from the arthritic temporomandibular joint and its relation to pain, mobility, and anterior open bite.J Oral Maxillofac Surg. 1998 Sep;56(9):1059-65; discussion 1066. doi: 10.1016/s0278-2391(98)90256-7. J Oral Maxillofac Surg. 1998. PMID: 9734768
-
Neuropeptides in the arthritic TMJ and symptoms and signs from the stomatognathic system with special consideration to rheumatoid arthritis.J Orofac Pain. 1995 Summer;9(3):215-25. J Orofac Pain. 1995. PMID: 8995921
-
Interleukin-1beta, interleukin-1 receptor antagonist, and interleukin-1 soluble receptor II in temporomandibular joint synovial fluid from patients with chronic polyarthritides.J Oral Maxillofac Surg. 2003 Oct;61(10):1171-8. doi: 10.1016/s0278-2391(03)00678-5. J Oral Maxillofac Surg. 2003. PMID: 14586853
-
Topical review: new insights into the pathology and diagnosis of disorders of the temporomandibular joint.J Orofac Pain. 2004 Summer;18(3):181-91. J Orofac Pain. 2004. PMID: 15508997 Review.
Cited by
-
Orofacial pain and headache: a review and look at the commonalities.Curr Pain Headache Rep. 2014 Mar;18(3):400. doi: 10.1007/s11916-013-0400-5. Curr Pain Headache Rep. 2014. PMID: 24500638 Review.
-
Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat.Neuroscience. 2012 Feb 17;203:207-15. doi: 10.1016/j.neuroscience.2011.12.019. Epub 2011 Dec 20. Neuroscience. 2012. PMID: 22209919 Free PMC article.
-
Phenotypic alterations of neuropeptide Y and calcitonin gene-related peptide-containing neurons innervating the rat temporomandibular joint during carrageenan-induced arthritis.Eur J Histochem. 2012 Oct 1;56(3):e31. doi: 10.4081/ejh.2012.e31. Eur J Histochem. 2012. PMID: 23027347 Free PMC article.
-
Temporomandibular joint pain and dysfunction.Curr Pain Headache Rep. 2006 Dec;10(6):408-14. doi: 10.1007/s11916-006-0070-7. Curr Pain Headache Rep. 2006. PMID: 17087864 Review.
-
Role of Intra-articular Piroxicam in the Temporomandibular Joint After Arthrocentesis for Anterior Disc Displacement Without Reduction.Cureus. 2023 Feb 3;15(2):e34580. doi: 10.7759/cureus.34580. eCollection 2023 Feb. Cureus. 2023. PMID: 36891013 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous