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Clinical Trial
. 1997 Nov;50(11):944-6.
doi: 10.1136/jcp.50.11.944.

Serological response of patients infected with Salmonella typhi

H Chart  1 , B Rowe, J S Cheesbrough
Affiliations
Clinical Trial

Serological response of patients infected with Salmonella typhi

H Chart et al. J Clin Pathol. 1997 Nov.

Abstract

Aims: To evaluate a rapid immunoblotting procedure for providing evidence of infection with Salmonella typhi using 73 sera from patients infected with S typhi.

Methods: A sodium dodecyl sulphatepolyacrylamide gel electrophoresis (SDS-PAGE)/immunoblotting procedure using lipopolysaccharide (LPS, O = 9,12) and flagellar (H = d) antigens was used.

Results: Seventy two of 73 sera contained antibodies to LPS, 40 sera also contained antibodies to H = d flagellar antigens. Analysis of acute and convalescent sera showed that only 62% of patients produced antibodies to flagellar antigens.

Conclusions: The SDS-PAGE/immunoblotting procedure provided a rapid method for providing serological evidence of infection with S typhi.

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