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Case Reports
. 1997 Nov;431(5):359-63.
doi: 10.1007/s004280050111.

Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica

K Tajima  1 , M Yamakawa, T Katagiri, H Sasaki
Affiliations
Case Reports

Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica

K Tajima et al. Virchows Arch. 1997 Nov.

Abstract

Tracheopathia osteochondroplastica (TO) is an unusual condition characterized by cartilaginous or bony submucosal nodules in the tracheobronchial tree. Bone morphogenetic protein-2 (BMP-2) and transforming growth factor beta-1 (TGF-beta 1) are potent inducers for new bone formation. We studied the precise localization of BMP-2 and TGF-beta 1 in two autopsied cases of TO, using immunohistochemical methods. Positive BMP-2 immunoreactivity was detected in numerous mesenchymal cells and chondroblasts lining the nodules in the tracheal submucosa. BMP-2 was not found in mature lamellar bony nodules. TGF-beta 1 was not seen in mesenchymal cells, though it did appear in chondrocytes and osteocytes in the nodules. These results suggest that BMP-2 plays an important role in nodule formation and acts synergistically with TGF-beta 1 to promote the nodules inductive cascade in the tracheal submucosa.

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