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Review
. 1998 Jan;56(1):29-35.

[The function of human cytomegalovirus genes]

[Article in Japanese]
Y Nishiyama  1
Affiliations
  • PMID: 9465661
Review

[The function of human cytomegalovirus genes]

[Article in Japanese]
Y Nishiyama. Nihon Rinsho. 1998 Jan.

Abstract

The genome of human cytomegalovirus(HCMV) has been completely sequenced and encodes more than 200 genes. Approximately 40 genes have been identified as "core genes" which are conserved in other members of the herpesvirus family. These include a set of genes required for viral DNA replication and virion morphogenesis. The HCMV genome also encodes homologs of cellular gene products such as MHC class I heavy chain, T cell gamma chain receptor and C-C chemokine receptor. Several genes in the US region are involved in the down-regulation of MHC class I antigens, but little is currently known about the function of most of HCMV gene products. This paper briefly reviews the function of HCMV proteins.

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