[Monitoring of CMV infection after bone marrow transplantation]

Abstract

Cytomegalovirus interstitial pneumonitis (CMV-IP) is one of the most serious complication after allogeneic stem cell transplantation. In the recent reports, ganciclovir administration have been shown to be effective for CMV infection by using more sensitive detection methods such as PCR method and antigenemia assay. The risk factors of CMV infection pretransplant time are known as follows, such as 1. unrelated donor marrow, 2. TBI, 3. anti thymocyte globulin, 4. T cell depletion and 5. HLA mismatched donor. After transplantation period 1. acute GVHD and 2. use of steroid hormone are important risk factors. It is necessary to select the effective strategy for the prevention of CMV-IP after stem cell transplantation.