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Comparative Study
. 1998 Feb;36(2):589-91.
doi: 10.1128/JCM.36.2.589-591.1998.

Comparison of use of cerebrospinal fluid, serum, and throat swab specimens in diagnosis of enteroviral acute neurological infection by a rapid RNA detection PCR assay

L Andréoletti  1 , N Blassel-Damman, A Dewilde, L Vallée, R Cremer, D Hober, P Wattré
Affiliations
Comparative Study

Comparison of use of cerebrospinal fluid, serum, and throat swab specimens in diagnosis of enteroviral acute neurological infection by a rapid RNA detection PCR assay

L Andréoletti et al. J Clin Microbiol. 1998 Feb.

Abstract

A PCR assay for detection of enterovirus RNA in multiple specimen types from patients with neurological infections was evaluated. Combined PCR assay of cerebrospinal fluid and serum (systemic specimens) was more sensitive than assaying either specimen alone in children but not in adults. Compared with PCR in systemic specimens, detection of enterovirus RNA in throat swabs showed a sensitivity of 62.5% and a specificity of 75.6%.

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References

    1. Abzug M J, Loeffelholz M, Rotbart H A. Diagnosis of neonatal enterovirus infection by polymerase chain reaction. J Pediatr. 1995;126:447–450. - PubMed
    1. Andréoletti L, Hober D, Belaich S, Lobert P E, Dewilde A, Wattré P. Rapid detection of enterovirus in clinical specimens using PCR and microwell capture hybridization assay. J Virol Methods. 1996;62:1–10. - PubMed
    1. Berlin L E, Rorabaugh M L, Heldrich F, Roberts K, Doran T, Modlin J F. Aseptic meningitis in infants <2 years of age: diagnosis and etiology. J Infect Dis. 1993;168:888–892. - PubMed
    1. Chonmaitree T, Ford C, Sanders C, Lucia H. Comparison of cell cultures for rapid isolation of enteroviruses. J Clin Microbiol. 1988;26:2576–2580. - PMC - PubMed
    1. Dagan R, Jenista J A, Prather S L, Powell K R, Menegus M A. Viremia in hospitalized children with enterovirus infections. J Pediatr. 1984;104:397–401. - PubMed

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