Effects of megestrol on oestradiol induced growth of the prostatic lobes and the seminal vesicles in castrated rats
- PMID: 946712
- DOI: 10.1530/acta.0.0820213
Effects of megestrol on oestradiol induced growth of the prostatic lobes and the seminal vesicles in castrated rats
Abstract
PIP: The effects of megestrol on estradiol induced growth of the prostatic lobes and the seminal vesicles in castrated rats were investigated. .01 mg estradiol/day or .02 or 2 mg megestrol/day was administered for 21 days alone or in combination. Estradiol had an androgenlike action inducing epithelial growth and secretory activity in the ventral and dorsolateral epithelium. Estradiol induced an increased fibromuscular growth in the seminal vesicles. 2 mg megestrol had a slight stimulating effect on the growth of the epithelium of the dorsal part of the dorsolateral prostate, the coagulating glands and the seminal vesicles. 2 mg megestrol alone or with estradiol reduced the adrenal weight to about a 3rd of that of the controls. .02 mg megestrol had no demonstrated effect of its own, acted synergistically with estradiol in stimulating epithelial growth in the ventral and dorsolateral prostate. The adrenal depressant dose of megestrol counteracted the effect of estradiol. 2 mg megestrol counteracted the increased fibromuscular growth seen in the coagulating glands and seminal vesicles after estradiol alone and caused a pronounced epithelial proliferation. These results demonstrate that it is not possible to postulate the effects of a steroid on male reproductive organs from effects obtained in the female. Statistical analyses are included.
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