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. 1998 Feb 1;81(3):333-5.
doi: 10.1016/s0002-9149(97)00904-1.

Effect of simvastatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study (4S)

T R Pedersen  1 , J Kjekshus, K Pyörälä, A G Olsson, T J Cook, T A Musliner, J A Tobert, T Haghfelt
Affiliations

Effect of simvastatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study (4S)

T R Pedersen et al. Am J Cardiol. .

Abstract

In patients participating in the Scandinavian Simvastatin Survival Study, cholesterol lowering with simvastatin reduced the incidence of carotid bruits and cerebrovascular events as well as new-onset or worsening of angina pectoris and intermittent claudication. These effects suggest that simvastatin may have a general antiatherosclerotic effect not limited to the coronary bed.

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