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. 1998 Jan 16;421(3):277-9.
doi: 10.1016/s0014-5793(97)01572-x.

Resveratrol, a remarkable inhibitor of ribonucleotide reductase

M Fontecave  1 , M Lepoivre, E Elleingand, C Gerez, O Guittet
Affiliations
Free article

Resveratrol, a remarkable inhibitor of ribonucleotide reductase

M Fontecave et al. FEBS Lett. .
Free article

Abstract

Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.

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