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. 1976 Mar;7(3):323-9.
doi: 10.1016/0092-8674(76)90161-6.

Absence of messenger RNA and gene DNA for beta-globin chains in hereditary persistence of fetal hemoglobin

B G Forget, D G Hillman, H Lazarus, E F Barell, J R Benz ej, C T Caskey, T H Huisman, W A Schroeder, D Housman

Absence of messenger RNA and gene DNA for beta-globin chains in hereditary persistence of fetal hemoglobin

B G Forget et al. Cell. 1976 Mar.

Abstract

The relative amounts of alpha-amd beta-globin mRNA and globin gene DNA were measured in reticulocyte RNA and lymphocyte DNA of an individual with homozygous hereditary persistence of fetal hemoglobin whose red blood cells contain 100% fetal hemoglobin (hb F: alpha2gamma2.) Molecular hybridization assays used as probes full-length DNA copies of human alpha- and beta-globin messenger RNA. The results of these hybridization assays demonstrated the expected amounts of alpha-globin mRNA and gene DNA, but absence of beta-globin mRNA and absence of beta-globin gene DNA. In the individual studied, hereditary persistence of fetal hemoglobin is associated with total deletion of the beta-globin structural gene.

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