Comparison of insulin regimens and administration modalities in pregnancy complicated by diabetes

Abstract

Purpose: To compare insulin administration using premixed insulin (70% NPH/30% Regular) by an injectable pen with traditional self-mixed insulin administered by syringe.

Methods: In this study, 93 women were enrolled into four groups.: 1) self-mixed/syringe, 2) premixed/syringe, 3) self-mixed/pen, and 4) premixed/pen.

Results: Women in the premixed pen group had significantly less cesarean deliveries for failure to progress in labor and a decrease (not significant) in postpartum infection and infant macrosomia. Patients felt premixed insulin administered by the pen was easier to use. No significant differences were noted in glucose control, compliance among the four groups, or cost.

Conclusion: Premixed insulin administration via the pen is safe, effective and no more costly than traditional treatment for pregnant diabetic women.