[Colitis in laboratory experimentation]

Abstract

Immunological concept of pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) is presently most common but it's specific etiology is still unknown. Spontaneous manifestations of these disease in animal are very rare and ad adequate laboratory animal model is needed for research. In this review different animal models of colitis are present in chronological order, displaying the search for the highest similarity to the clinical colitis.