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. 1998 Mar 1;330 ( Pt 2)(Pt 2):599-603.
doi: 10.1042/bj3300599.

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes

D Thomas  1 , H Y Kim, R Morgan, M R Hanley
Affiliations

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes

D Thomas et al. Biochem J. .

Abstract

Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.

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